The future of intensive care: the study of the microcirculation will help to guide our therapies
The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
Endothelial damage and the microcirculation in critical illness
Endothelial integrity maintains microcirculatory flow and tissue oxygen delivery. The
endothelial glycocalyx is involved in cell signalling, coagulation and inflammation. Our …
endothelial glycocalyx is involved in cell signalling, coagulation and inflammation. Our …
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study
A Rovas, J Sackarnd, J Rossaint, S Kampmeier… - Critical Care, 2021 - Springer
Background The availability of handheld, noninvasive sublingual video-microscopes allows
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …
for visualization of the microcirculation in critically ill patients. Recent studies demonstrate …
Association of sublingual microcirculation parameters and capillary refill time in the early phase of ICU admission
W Huang, H Xiang, C Hu, T Wu, D Zhang… - Critical care …, 2023 - journals.lww.com
Objectives: This observational study was conducted to investigate capillary refill time (CRT)
during the early phase of ICU admission in relationship with microvascular flow alteration …
during the early phase of ICU admission in relationship with microvascular flow alteration …
Automated algorithm analysis of sublingual microcirculation in an international multicentral database identifies alterations associated with disease and mechanism of …
Objectives: Reliable automated handheld vital microscopy image sequence analysis and
the identification of disease states and effects of therapy are prerequisites for the routine use …
the identification of disease states and effects of therapy are prerequisites for the routine use …
Shear stress and endothelial mechanotransduction in trauma patients with hemorrhagic shock: hidden coagulopathy pathways and novel therapeutic strategies
A Chalkias - International Journal of Molecular Sciences, 2023 - mdpi.com
Massive trauma remains a leading cause of death and a global public health burden. Post-
traumatic coagulopathy may be present even before the onset of resuscitation, and …
traumatic coagulopathy may be present even before the onset of resuscitation, and …
Low microcirculatory perfused vessel density and high heterogeneity are associated with increased intensity and duration of lactic acidosis after cardiac surgery with …
Methods: We measured sublingual microcirculation using incident darkfield video
microscopy in 50 subjects on intensive care unit admission after cardiac surgery. Serial …
microscopy in 50 subjects on intensive care unit admission after cardiac surgery. Serial …
Severe impairment of microcirculatory perfused vessel density is associated with postoperative lactate and acute organ injury after cardiac surgery
JC Greenwood, DH Jang, SD Hallisey… - Journal of cardiothoracic …, 2021 - Elsevier
Objective Resuscitation after cardiac surgery needs to address multiple pathophysiological
processes that are associated with significant morbidity and mortality. Functional …
processes that are associated with significant morbidity and mortality. Functional …
Fluid therapy and the microcirculation in health and critical illness
ES Cooper, DC Silverstein - Frontiers in veterinary science, 2021 - frontiersin.org
Fluid selection and administration during shock is typically guided by consideration of
macrovascular abnormalities and resuscitative targets (perfusion parameters, heart rate …
macrovascular abnormalities and resuscitative targets (perfusion parameters, heart rate …
Microcirculatory tissue perfusion during general anaesthesia and noncardiac surgery: an observational study using incident dark field imaging with automated video …
M Flick, TH Schreiber, J Montomoli… - European Journal of …, 2022 - journals.lww.com
BACKGROUND Handheld vital microscopy allows direct observation of red blood cells
within the sublingual microcirculation. Automated analysis allows quantifying …
within the sublingual microcirculation. Automated analysis allows quantifying …