Within human medicine, it is recognized that the pharmacokinetics (PK) of many compounds
can be altered by the presence of inflammation or infection. Research into the reason for …

Objective—To determine whether pharmacokinetics and milk elimination of flunixin and 5-
hydroxy flunixin differed between healthy and mastitic cows. Design—Prospective controlled …

Ceftriaxone (CTX) is a third-generation cephalosporin that has proven to be effective in the
treatment of infections caused by a wide range of gram-positive and gram-negative …

Hepatopathy sometimes may interfere with metabolism and/or elimination of drugs which
undergo major hepatic clearance. Twelve healthy goats were equally divided into two …

The objective of this study was to evaluate the pharmacokinetics of CTX following
intravenous administration of ascending doses in sheep. In this study, six clinically healthy …

Milk is a food containing many biologically active substances that have an important place in
the nourishment of newborns and adults. The transition of the drugs used in the treatment …

Disposition of antimicrobials is known to be altered during disease conditions and fever is
one of the common manifestations of bacterial infections in animals. The disposition of …

The pharmacokinetic parameters of cephradine (20 mg/kg b. wt.) were studied following
intravenous (IV) and oral (PO)(single and repeated) administrations in healthy and …

The pharmacokinetics (after single intravenous and oral dose) and tissue residues (orally
and daily for five days) of cephradine (20 mg/kg b. wt.) were investigated in healthy and …

Sažetak The disposition of cefpirome after single intramuscular (im) administration (10 mg.
kg-1) was investigated in five male cross-bred calves and in vitro plasma protein binding …