ESX secretion systems: mycobacterial evolution to counter host immunity
MI Gröschel, F Sayes, R Simeone, L Majlessi… - Nature Reviews …, 2016 - nature.com
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
[HTML][HTML] Take five—Type VII secretion systems of Mycobacteria
Mycobacteria use type VII secretion (T7S) systems to secrete proteins across their complex
cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium …
cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium …
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence
JAM Tufariello, JR Chapman… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
A Mehra, A Zahra, V Thompson… - PLoS …, 2013 - journals.plos.org
Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …
The structure of the endogenous ESX-3 secretion system
N Poweleit, N Czudnochowski, R Nakagawa… - Elife, 2019 - elifesciences.org
The ESX (or Type VII) secretion systems are protein export systems in mycobacteria and
many Gram-positive bacteria that mediate a broad range of functions including virulence …
many Gram-positive bacteria that mediate a broad range of functions including virulence …
Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages
Containment of Mycobacterium tuberculosis (Mtb) infection requires T cell recognition of
infected macrophages. Mtb has evolved to tolerate, evade, and subvert host immunity …
infected macrophages. Mtb has evolved to tolerate, evade, and subvert host immunity …
Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis
J Augenstreich, V Briken - Frontiers in cellular and infection …, 2020 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …
The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis
A Serafini, D Pisu, G Palù, GM Rodriguez… - PloS one, 2013 - journals.plos.org
ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium
tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis …
tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis …
Type VII secretion: a highly versatile secretion system
Bacterial secretion systems were initially studied in the Gram‐negative bacterium
Escherichia coli K‐12. When researchers started to explore protein secretion in different …
Escherichia coli K‐12. When researchers started to explore protein secretion in different …
Structure of EspB from the ESX-1 type VII secretion system and insights into its export mechanism
Mycobacterium tuberculosis (Mtb) uses the ESX-1 type VII secretion system to export
virulence proteins across its lipid-rich cell wall, which helps permeabilize the host's …
virulence proteins across its lipid-rich cell wall, which helps permeabilize the host's …