Adaptive optics is becoming a valuable tool for high resolution microscopy, providing
correction for aberrations introduced by the refractive index structure of specimens. This is …

Microscopic evaluation of resected tissue plays a central role in the surgical management of
cancer. Because optical microscopes have a limited depth-of-field (DOF), resected tissue is …

Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult
brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens …

Ultra-miniaturized microendoscopes are vital for numerous biomedical applications. Such
minimally invasive imagers allow for navigation into hard-to-reach regions and observation …

A fiber bundle is widely used for endoscopic imaging due to its direct image delivery
capability. However, there exists an inevitable pixelation artifact, which limits spatial …

The advance of genetic function indicators has enabled the observation of neuronal
activities at single-cell resolutions. A major challenge for the applications on mammalian …

Imaging neuronal activity with high and homogeneous spatial resolution across the field-of-
view (FOV) and limited invasiveness in deep brain regions is fundamental for the progress of …

Inherent aberrations of gradient index (GRIN) lenses used in fluorescence endomicroscopes
deteriorate imaging performance. Using adaptive optics, we characterized and corrected the …

Miniature handheld imaging devices and endoscopes based on coherent Raman scattering
are promising for label-free in vivo optical diagnosis. Toward the development of these small …

Here we demonstrate widefield (field diameter= 200 μm) fluorescence microscopy and video
imaging inside the rodent brain at a depth of 2 mm using a simple surgical glass needle …