ZNF143 in chromatin looping and gene regulation

B Ye, G Yang, Y Li, C Zhang, Q Wang, G Yu - Frontiers in genetics, 2020 - frontiersin.org
ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein
consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence …

SOXC transcription factors as diagnostic biomarkers and therapeutic targets for arthritis

EA Ahmed, AM Alzahrani - International Journal of Molecular Sciences, 2023 - mdpi.com
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common disorders that disrupt the
quality of life of millions of people. These two chronic diseases cause damage to the joint …

[HTML][HTML] ZNF143 is a transcriptional regulator of nuclear-encoded mitochondrial genes that acts independently of looping and CTCF

MD Magnitov, M Maresca, NA Saiz, H Teunissen… - Molecular Cell, 2025 - cell.com
Gene expression is orchestrated by transcription factors, which function within the context of
a three-dimensional genome. Zinc-finger protein 143 (ZNF143/ZFP143) is a transcription …

Genome-wide inference reveals that feedback regulations constrain promoter-dependent transcriptional burst kinetics

S Luo, Z Wang, Z Zhang, T Zhou… - Nucleic Acids …, 2023 - academic.oup.com
Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …

The RNA exosome nuclease complex regulates human embryonic stem cell differentiation

C Belair, S Sim, KY Kim, Y Tanaka, IH Park… - Journal of Cell …, 2019 - rupress.org
A defining feature of embryonic stem cells (ESCs) is the ability to differentiate into all three
germ layers. Pluripotency is maintained in part by a unique transcription network that …

SOX4 and RELA function as transcriptional partners to regulate the expression of TNF-responsive genes in fibroblast-like synoviocytes

K Jones, S Ramirez-Perez, S Niu… - Frontiers in …, 2022 - frontiersin.org
SOX4 belongs to the group C of the SOX transcription factor family. It is a critical mediator of
tumor necrosis factor alpha (TNF)-induced transformation of fibroblast-like s-ynoviocytes …

Genetic Disruption of the Sh3pxd2a Gene Reveals an Essential Role in Mouse Development and the Existence of a Novel Isoform of Tks5

P Cejudo-Martin, A Yuen, N Vlahovich, P Lock… - PLoS …, 2014 - journals.plos.org
Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation
through its essential role in invadosome formation and function. We have previously …

The ubiquitous transcriptional protein ZNF143 activates a diversity of genes while assisting to organize chromatin structure

L Huning, GR Kunkel - Gene, 2021 - Elsevier
Abstract Zinc Finger Protein 143 (ZNF143) is a pervasive C2H2 zinc-finger transcriptional
activator protein regulating the efficiency of eukaryotic promoter regions. ZNF143 is able to …

Type 2 diabetes mellitus and cardiovascular risk; what the pharmacotherapy can change through the epigenetics

PA Andreeva–Gateva, ID Mihaleva… - Postgraduate …, 2020 - Taylor & Francis
Diabetes mellitus and cardiovascular diseases are part of the metabolic syndrome and
share similar risk factors, including obesity, arterial hypertension, and dyslipidemia …

[HTML][HTML] Zinc finger protein 143 expression is closely related to tumor malignancy via regulating cell motility in breast cancer

AR Paek, JY Mun, KM Hong, J Lee, DW Hong… - BMB reports, 2017 - ncbi.nlm.nih.gov
We previously reported the involvement of zinc-finger protein 143 (ZNF143) on cancer cell
motility in colon cancer cells. Here, ZNF143 was further characterized in breast cancer …