Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

A Nakamura, S Kurihara, D Takahashi… - Nature …, 2021 - nature.com
Intestinal microbiota-derived metabolites have biological importance for the host.
Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota …

Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

L Wampach, A Heintz-Buschart, JV Fritz… - Nature …, 2018 - nature.com
The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear
whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and …

Prevalence and Some Possible Mechanisms of Colistin Resistance Among Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa

RM Abd El-Baky, SM Masoud… - Infection and Drug …, 2020 - Taylor & Francis
Background and Aim The emergence of colistin-resistant strains is considered a great threat
for patients with severe infections. Here, we investigate the prevalence and some possible …

Colistin-phage combinations decrease antibiotic resistance in Acinetobacter baumannii via changes in envelope architecture

X Wang, B Loh, F Gordillo Altamirano, Y Yu… - Emerging microbes & …, 2021 - Taylor & Francis
Multidrug-resistant bacterial infections are becoming increasingly common, with only few
last-resort antibiotics such as colistin available for clinical therapy. An alternative therapeutic …

Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections

H Chung, C Merakou, MM Schaefers, KB Flett… - Nature …, 2022 - nature.com
Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy
updated during treatment. The effects of such rapid antibiotic switching on the evolution of …

The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae

I Leduc, KL Connolly, A Begum, K Underwood… - PLoS …, 2020 - journals.plos.org
There is a pressing need for a gonorrhea vaccine due to the high disease burden
associated with gonococcal infections globally and the rapid evolution of antibiotic …

A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response

JC Evans, VL McEneany, MJ Coyne… - Nature …, 2022 - nature.com
Phocaeicola vulgatus is one of the most abundant and ubiquitous bacterial species of the
human gut microbiota, yet a comprehensive analysis of antibacterial toxin production by …

Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations

PD Scanlan, AR Hall, G Blackshields… - Molecular biology …, 2015 - academic.oup.com
Studies of antagonistic coevolution between hosts and parasites typically focus on
resistance and infectivity traits. However, coevolution could also have genome-wide effects …

Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2

C Martin-Gallausiaux, A Malabirade, J Habier… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EVs) derived from the gut microbiota are largely uncharacterized and
their impacts on host intestinal physiology remain unresolved. Here, we isolated EVs from F …

Odontogenic infection by Porphyromonas gingivalis exacerbates fibrosis in NASH via hepatic stellate cell activation

A Nagasaki, S Sakamoto, C Chea, E Ishida… - Scientific reports, 2020 - nature.com
Odontogenic infection of Porphyromonas gingivalis (Pg.), a major periodontal pathogen,
exacerbates pathological progression of non-alcoholic steatohepatitis (NASH). In this study …