Carbapenem resistance is a major global health problem that seriously compromises the
treatment of infections caused by nosocomial pathogens. Resistance to carbapenems …

Class C β-lactamases or cephalosporinases can be classified into two functional groups (1,
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

Serial femtosecond crystallography has opened up many new opportunities in structural
biology. In recent years, several approaches employing light-inducible systems have …

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma
correlated with poor patient survival. There are no curative treatments for GB, and it …

Since the discovery of penicillin by Alexander Fleming in 1929 as a therapeutic agent
against staphylococci, β-lactam antibiotics (BLAs) remained the most successful antibiotic …

β-Lactams have been a clinical focus since their emergence and indeed act as a powerful
tool to combat severe bacterial infections, but their effectiveness is threatened by drug …

Taniborbactam (formerly known as VNRX-5133) is a novel bicyclic boronate β-lactamase
inhibitor of serine β-lactamases (SBLs)[Ambler classes A, C, and D] and metallo-β …

Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a
major global health concern associated with the emergence of new β-lactamases (BLAs) as …

β-Lactams are the most important class of antibacterials, but their use is increasingly
compromised by resistance, most importantly via serine β-lactamase (SBL)-catalyzed …