An immune atlas of T cells in transplant rejection: pathways and therapeutic opportunities

S Short, G Lewik, F Issa - Transplantation, 2023 - journals.lww.com
Short-term outcomes in allotransplantation are excellent due to technical and
pharmacological advances; however, improvement in long-term outcomes has been limited …

Role of the immune system in liver transplantation and its implications for therapeutic interventions

G Chen, X Hu, Y Huang, X Xiang, S Pan, R Chen… - MedComm, 2023 - Wiley Online Library
Liver transplantation (LT) stands as the gold standard for treating end‐stage liver disease
and hepatocellular carcinoma, yet postoperative complications continue to impact survival …

RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice.

AA Joshi, Y Wu, S Deng, P Preston-Hurlburt… - Clinical …, 2022 - Elsevier
The receptor for advanced glycation endproducts (RAGE) is involved in multiple
inflammatory processes. RAGE participates in adaptive and innate immune responses but …

Evolving landscape in liver transplantation for hepatocellular carcinoma: from stage migration to immunotherapy revolution

S Cesario, V Genovesi, F Salani, E Vasile, L Fornaro… - Life, 2023 - mdpi.com
Liver transplantation (LT) represents the primary curative option for HCC. Despite the
extension of transplantation criteria and conversion with down-staging loco-regional …

[HTML][HTML] Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity

T Nakano, S Goto, CL Chen - International Journal of Molecular Sciences, 2024 - mdpi.com
Since the first published report of experimental kidney transplantation in dogs in 1902, there
were many experimental and clinical trials of organ transplantation, with many sacrifices …

T helper-9 cells and Interleukin-9 in transplantation: The open question

S Assadiasl, Y Fatahi, MH Nicknam - Human Immunology, 2022 - Elsevier
The role of main TCD4+ lymphocyte subsets including T helper 1 (Th1), Th2, Th17, and T
regulatory cells in transplantation has already been described; however, the implication of …

Innate and Adaptive Immune Responses in Intestinal Transplant Rejection: Through the Lens of Inflammatory Bowel and Intestinal Graft-Versus-Host Diseases

Y Cui, RG Hackett, J Ascue… - Gastroenterology …, 2024 - gastro.theclinics.com
Intestinal failure (IF) is a dysfunctional condition wherein the gastrointestinal (GI) tract is
unable to fulfill its essential functions of food digestion and absorption. 1 Approximately …

Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales

A M. Zand, S Anastassov, T Frei, M Khammash - bioRxiv, 2024 - biorxiv.org
Integral feedback control strategies have proven effective in regulating protein expression in
unpredictable cellular environments. These strategies, grounded in model-based designs …

[HTML][HTML] Targeting T helper 17 cells: emerging strategies for overcoming transplant rejection

YJ Lee, ML Cho - Clinical Transplantation and Research, 2024 - pmc.ncbi.nlm.nih.gov
Solid organ transplantation has significantly improved the survival rate of patients with
terminal organ failure. However, its success is often compromised by allograft rejection, a …

T helperl/T helper2 and Interferon-y/Interleuldn-10 Ratios in Liver Transplant Rejection.

S Assadiasl, MN Toosi, N Soleimanifar… - Journal of Basic …, 2024 - search.ebscohost.com
Introduction: Immune monitoring in transplant recipients, examining lymphocyte subsets and
cytokine levels, is pivotal for advancing individualized medicine in transplantation. This …