Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical …

M Bialer, SI Johannessen, MJ Koepp, RH Levy… - …, 2020 - Wiley Online Library
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …

Moving beyond sodium valproate: choosing the right anti-epileptic drug in children

G Balagura, G Iapadre, A Verrotti… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Sodium valproate is a widely used anti-epileptic drug with a broad spectrum of
activity and mechanism of action. It has consequently been the first-line drug for most …

Phenobarbital as alternate anticonvulsant for organophosphate‐induced benzodiazepine‐refractory status epilepticus and neuronal injury

DS Reddy, D Perumal, V Golub, A Habib… - Epilepsia …, 2020 - Wiley Online Library
Abstract Objective Organophosphates (OPs) such as diisopropylfluorophosphate (DFP) and
soman are lethal chemical agents that can produce seizures, refractory status epilepticus …

Refractory and super-refractory status epilepticus in nerve agent-poisoned rats following application of standard clinical treatment guidelines

JE Morgan, SC Wilson, BJ Travis, KH Bagri… - Frontiers in …, 2021 - frontiersin.org
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus
(SE). Current guidelines for treatment of NA-induced SE only include prehospital …

Synthesis of a novel amide derivative of valproic acid and 1, 3, 4-thiadiazole with antiepileptic activity

AS Malygin, D Ma, S Sya, S Ev - Bulletin of Russian State Medical …, 2020 - cyberleninka.ru
Valproates are commonly used to treat various forms of epilepsy. Problems accompanying
their clinical application include drug resistance, adverse effects, acute and chronic toxicity …

The effect of Phenobarbital and Diclofenac on Neurological Convulsion in Chicks as A model

Z Ahmed, M Fadel - Egyptian Journal of Veterinary Sciences, 2024 - ejvs.journals.ekb.eg
Background: Phenobarbital is one of antiepileptic drugs. Diclofenac is one of NSAID.
Objective: The purpose of carrying out this research was to determine the effect of both …

[HTML][HTML] Study of the anticonvulsant activity of the original valproic acid amino ester in various models of convulsive syndrome

AS Melekhova, EB Shustov, VN Zorina… - Toksikologicheskiy …, 2023 - j-morphology.com
Introduction. Despite a significant number of antidotes (atropine, pyridoxine) and anti-
seizure drugs in clinical practice (benzodiazepines, barbiturates, valproates, anesthetics) …

Методы профилактики и терапии судорожного синдрома при отравлении конвульсантами холинергического ряда

ВН Зорина, ЕА Евдокимова… - Медицина …, 2024 - extrememedicine.ru
Аннотация Фосфорорганические соединения (ФОС) и карбаматы—распространенная
причина отравлений, ассоциированных с развитием судорожного синдрома. Эти …

[HTML][HTML] МЕТОДЫ ПРОФИЛАКТИКИ И ТЕРАПИИ СУДОРОЖНОГО СИНДРОМА ПРИ ОТРАВЛЕНИИ КОНВУЛЬСАНТАМИ ХОЛИНЕРГИЧЕСКОГО РЯДА

ЕА Евдокимова, ВЛ Рейнюк - Медицина экстремальных ситуаций, 2022 - cyberleninka.ru
Фосфорорганические соединения (ФОС) и карбаматы—распространенная причина
отравлений, ассоциированных с развитием судорожного синдрома. Эти …

Pharmacokinetic and pharmacodynamic analysis of (2S,3S)‐sec‐butylpropylacetamide (SPD) in rats and pigs—A CNS‐active stereoisomer of SPD

D Bibi, M Bialer - Epilepsia, 2020 - Wiley Online Library
Objectives To advance the development of (2S, 3S)‐sec‐butylpropylacetamide (SPD) as a
new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in …