The brain is one of the major target organs of alcohol actions. Alcohol abuse can lead to
alterations in brain structure and functions and, in some cases, to neurodegeneration …

The excessive intake of alcohol is a serious public health problem, especially given the
severe damage provoked by chronic or prenatal exposure to alcohol that affects many …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

Maternal alcohol exposure during pregnancy can substantially impact the development of
the fetus, causing a range of symptoms, known as fetal alcohol spectrum disorders (FASDs) …

Alcohol consumption during pregnancy can produce a variety of central nervous system
(CNS) abnormalities in the offspring resulting in a broad spectrum of cognitive and …

We conducted meta-analyses of relationships between highly prevalent substance use
during pregnancy and offspring conduct disorder problems. In total 36 studies were …

Endocannabinoids regulate brain development via modulating neural proliferation,
migration, and the differentiation of lineage-committed cells. In the fetal nervous …

During the last 20 years, new and exciting roles for glial cells in brain development have
been described. Moreover, several recent studies implicated glial cells in the pathogenesis …

Adolescence has been identified as a vulnerable developmental time period during which
exposure to drugs can have long-lasting, detrimental effects. Although adolescent binge-like …

Alcohol exposure during central nervous system (CNS) development can lead to fetal
alcohol spectrum disorder (FASD). Human imaging studies have revealed significant white …