Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Invadosomes and caveolae are mechanosensitive structures that are implicated in
metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix …

Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …

Physical properties of tissue are increasingly recognised as major regulatory cues affecting
cell behaviours, particularly cell migration. While these properties of the extracellular matrix …

The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …

Targeting the tumour immune microenvironment (TIME) by cancer immunotherapy has led to
improved patient outcomes. However, response to these treatments is heterogeneous and …

Immune cells are highly dynamic and able to migrate through environments with diverse
biochemical and mechanical compositions. Their migration has classically been defined as …