Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …

The dynamic nature of synaptic connections has presented morphologists with considerable
problems which, from a structural perspective, have frustrated the development of ideas on …

Calcium/calmodulin-stimulated autophosphorylation of a prominent brain calmodulin-
dependent protein kinase (Type II CaM kinase) produces dramatic changes in its enzymatic …

A mechanism is proposed for a molecular switch that can store information indefinitely,
despite the complete turnover of the molecules that make up the switch. The design of the …

A calcium and calmodulin-dependent protein kinase has been purified from rat brain. It was
monitored during the purification by its ability to phosphorylate the synaptic vesicle …

By three criteria, two biochemical and one immunochemical, the major postsynaptic density
protein (mPSDp) is indistinguishable from the 50-kilodalton (kDa) alpha subunit of a brain …

Polypeptides of Mr 50,000 and 60,000 in isolated synaptic junctions have been compared to
polypeptides of corresponding molecular weight in Ca2+/calmodulin-dependent protein …

We have shown previously that the subcellular distribution of a major calmodulin-binding
protein is altered under conditions causing increased synthesis of cAMP in Aplysia neurons …

A calcium/calmodulin-dependent protein kinase, which phosphorylates a synaptic vesicle-
associated protein designated Synapsin I, has been shown to be present in both soluble …

A theory is proposed that biochemical changes at the synapse that occur as a result of
stimulation of specific neuronal circuits can lead to long-term changes only if alterations …