Undoubtedly, one of the most interesting topics in the field of neuroscience is the ability of
the central nervous system to respond to different stimuli (normal or pathological) by …

Ghrelin is a gut peptide hormone associated with feeding behavior and energy homeostasis.
Acylated ghrelin binds to the growth hormone secretagogue receptor 1a subtype (GHS-R1a) …

NMDA receptors play crucial roles in excitatory synaptic transmission. Rare variants in
GRIN2A encoding the GluN2A subunit are associated with a spectrum of disorders, ranging …

The peroxisome proliferator-activated receptor gamma (PPARγ), which belongs to the family
of nuclear receptors, has been mainly studied as an important factor in metabolic disorders …

Compounds present in Cannabis sativa L. preparations have recently attracted much
attention in the treatment of drug-resistant epilepsy. Here, we screened two olive oil extracts …

Clinical data suggest that the neuroendocrine stress response is chronically dysregulated in
a subset of patients with temporal lobe epilepsy (TLE), potentially contributing to both …

Ghrelin, des-acyl ghrelin and other related peptides possess anticonvulsant activities.
Although ghrelin and cognate peptides were shown to physiologically regulate only the …

Antiepileptic drugs have been successfully treating epilepsy and providing individuals
sustained seizure freedom. However, about 30% of the patients with epilepsy present drug …

Reduced gamma-aminobutyric acid (GABA) inhibition has been implicated in both anxiety
and epilepsy. GAD65-/-(NOD/LtJ) mice have significantly decreased basal GABA levels in …

Objective Besides seizures, patients with epilepsy are affected by a variety of cognitive and
psychiatric comorbidities that further impair their quality of life. The present study provides an …