The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway.
The pro-apoptotic BCL-2 proteins BAX and BAK can commit a cell to its programmed death …

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient
deployment of mitochondrial tasks, organelle homeostasis needs to be preserved …

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

Mitochondria are membrane bound organelles present in almost all eukaryotic cells.
Responsible for orchestrating cellular energy production, they are central to the …

Mitochondria participate in apoptosis through a range of mechanisms that vary between
vertebrates and invertebrates. In vertebrates, they release intermembrane space proteins …

The central role of the Bcl-2 family in regulating apoptotic cell death was first identified in the
1980s. Since then, significant in-roads have been made in identifying the multiple members …

Apoptosis is a form of programmed cell death critical for the development and homeostasis
of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the …

The BCL-2 family of proteins control a key checkpoint in apoptosis, that of mitochondrial
outer membrane permeabilization or, simply, mitochondrial poration. The family consists of …