Structural mechanisms of NLRP3 inflammasome assembly and activation
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …
invasions and endogenous cellular damage and responds by forming the NLRP3 …
The NLRP3 inflammasome: activation and regulation
The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
Inflammasomes are intracellular protein complexes that drive the activation of inflammatory
caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have …
caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have …
Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach
NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
division of the cell. Over expression of NEK7 leads to the progression of different cancers …
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
H Shi, Y Wang, X Li, X Zhan, M Tang, M Fina, L Su… - Nature …, 2016 - nature.com
The NLRP3 inflammasome responds to microbes and danger signals by processing and
activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found …
activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found …
Structure, activation and regulation of NLRP3 and AIM2 inflammasomes
The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …
signaling platform that shields from multiple pathogenic infections by stimulating the …
Cell cycle regulation by the NEK family of protein kinases
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …
Post-translational regulation of inflammasomes
Inflammasomes play essential roles in immune protection against microbial infections.
However, excessive inflammation is implicated in various human diseases, including …
However, excessive inflammation is implicated in various human diseases, including …
Recent insights into the regulatory networks of NLRP3 inflammasome activation
ANR Weber, ZA Bittner, S Shankar, X Liu… - Journal of cell …, 2020 - journals.biologists.com
ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …