Purpose The objective of this review was to explore the potential clinical application of
unconventional non-amino acid PET radiopharmaceuticals in patients with gliomas …

Purpose: To analyze and review the progress of glucose metabolism-based molecular
imaging in detecting tumors to guide clinicians for new management strategies. Summary …

Despite the anti-proliferative and survival benefits from tumor treating fields (TTFields) in
human glioblastoma (hGBM), little is known about the effects of this form of alternating …

The development of gene delivery vehicles with high organ specificity when administered
systemically is a critical goal for gene therapy. We combine optical and positron emission …

Abstract Purpose: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key
process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) …

Background Aerobic glycolysis is a hallmark of glucose metabolism in cancer. Previous
studies have suggested that cancer cell–derived extracellular vesicles (EVs) can modulate …

Pyruvate kinase M2 (PKM2), a rate limiting enzyme in glycolysis, is a cellular regulator that
has received extensive attention and regards as a metabolic regulator of cellular metabolism …

Background Resistance to existing therapies is a significant challenge in improving
outcomes for glioblastoma (GBM) patients. Metabolic plasticity has emerged as an important …

Purpose The aim of this study was to develop a positron emission tomography (PET)
radiotracer for measuring pyruvate kinase M2 (PKM2) with improved physicochemical and …

BackgroundResistance to existing therapies is a significant challenge in improving
outcomes for glioblastoma (GBM) patients. Metabolic plasticity has emerged as an important …