Phage display technique as a tool for diagnosis and antibody selection for coronaviruses

T Anand, N Virmani, BC Bera, RK Vaid, M Vashisth… - Current …, 2021 - Springer
Phage display is one of the important and effective molecular biology techniques and has
remained indispensable for research community since its discovery in the year 1985. As a …

Phage display: an overview in context to drug discovery

S Mimmi, D Maisano, I Quinto, E Iaccino - Trends in pharmacological …, 2019 - cell.com
Peptides are emerging as a new reliable class of therapeutics and, thanks to their lower cost
of production, they are becoming established as perfect drug aspirants. Here, we briefly …

Application of bacteriophages in nanotechnology

J Paczesny, K Bielec - Nanomaterials, 2020 - mdpi.com
Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single
phage body virion, is a colloidal particle, often possessing a dipole moment. As such …

Past HIV-1 medications and the current status of combined antiretroviral therapy options for HIV-1 patients

M Weichseldorfer, M Reitz, OS Latinovic - Pharmaceutics, 2021 - mdpi.com
Combined antiretroviral therapy (cART) is treatment with a combination of several
antiretroviral drugs that block multiple stages in the virus replication cycle. An estimated 60 …

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes

E Iaccino, S Mimmi, V Dattilo, F Marino, P Candeloro… - Molecular cancer, 2017 - Springer
Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression,
and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there …

Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α

M Pontoriero, G Fiume, E Vecchio… - Journal of Molecular …, 2019 - Springer
The antigen-mediated triggering of B cell receptor (BCR) activates the transcription factor NF-
κB that regulates the expression of genes involved in B cell differentiation, proliferation, and …

Arming filamentous bacteriophage, a nature-made nanoparticle, for new vaccine and immunotherapeutic strategies

R Sartorius, L D'Apice, A Prisco, P De Berardinis - Pharmaceutics, 2019 - mdpi.com
The pharmaceutical use of bacteriophages as safe and inexpensive therapeutic tools is
collecting renewed interest. The use of lytic phages to fight antibiotic-resistant bacterial …

Metabolites profiling of melanoma interstitial fluids reveals uridine diphosphate as potent immune modulator capable of limiting tumor growth

E Vecchio, C Caiazza, S Mimmi, A Avagliano… - Frontiers in Cell and …, 2021 - frontiersin.org
Tumor interstitial fluid (TIF) surrounds and perfuses tumors and collects ions, metabolites,
proteins, and extracellular vesicles secreted by tumor and stromal cells. Specific …

Role of chronic lymphocytic leukemia (CLL)-derived exosomes in tumor progression and survival

N Nisticò, D Maisano, E Iaccino, E Vecchio, G Fiume… - Pharmaceuticals, 2020 - mdpi.com
Chronic lymphocytic leukemia (CLL) is a B-lymphoproliferative disease, which consists of
the abnormal proliferation of CD19/CD5/CD20/CD23 positive lymphocytes in blood and …

[HTML][HTML] Novel antigen delivery systems

M Trovato, P De Berardinis - World journal of virology, 2015 - ncbi.nlm.nih.gov
Vaccines represent the most relevant contribution of immunology to human health. However,
despite the remarkable success achieved in the past years, many vaccines are still missing …