Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

The prognostic role of circulating tumor cells (CTCs) has been clearly demonstrated in many
types of cancer. However, their roles in diagnostic and treatment strategies remain to be …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Cancers develop in complex tissue environments, which they depend on for sustained
growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor …

Breast cancer is now the most frequently diagnosed cancer and leading cause of cancer
death in women worldwide. Strategies targeting the primary tumour have markedly …

Abstract The CellSearch® system (CS) enables standardized enrichment and enumeration
of circulating tumor cells (CTCs) that are repeatedly assessable via non-invasive “liquid …

Background The identification of circulating tumour cells correlate with poor prognosis in
metastatic breast cancer, but there are few data describing the importance of circulating …

Importance Circulating tumor cells (CTCs) represent the liquid component of solid tumors
and are a surrogate marker for residual cancer burden. Although CTC status is prognostic of …

Circulating Tumor Cells (CTCs) are shed from primary or secondary tumors into blood
circulation. Accessing and analyzing these cells provides a non-invasive alternative to tissue …

Most breast cancer patients die due to metastases, and the early onset of this multistep
process is usually missed by current tumor staging modalities. Therefore, ultrasensitive …