Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association

JJ Joseph, P Deedwania, T Acharya, D Aguilar… - Circulation, 2022 - Am Heart Assoc
Cardiovascular disease remains the leading cause of death in patients with diabetes.
Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk …

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

[HTML][HTML] Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review

DB Fogel - Contemporary clinical trials communications, 2018 - Elsevier
Clinical trials are time consuming, expensive, and often burdensome on patients. Clinical
trials can fail for many reasons. This survey reviews many of these reasons and offers …

Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies

HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …

CC Low Wang, CN Hess, WR Hiatt, AB Goldfine - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

B Gross, M Pawlak, P Lefebvre, B Staels - Nature Reviews …, 2017 - nature.com
Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Impact of diabetes mellitus on hospitalization for heart failure, cardiovascular events, and death: outcomes at 4 years from the Reduction of Atherothrombosis for …

MA Cavender, PG Steg, SC Smith Jr, K Eagle… - Circulation, 2015 - Am Heart Assoc
Background—Despite the known association of diabetes mellitus with cardiovascular
events, there are few contemporary data on the long-term outcomes from international …

Novel therapies with precision mechanisms for type 2 diabetes mellitus

L Perreault, JS Skyler, J Rosenstock - Nature Reviews Endocrinology, 2021 - nature.com
Type 2 diabetes mellitus (T2DM) is one of the greatest health crises of our time and its
prevalence is projected to increase by> 50% globally by 2045. Currently, 10 classes of …