Paclitaxel is a broad‐spectrum anticancer compound, which was derived mainly from a
medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum
based therapy, the standard care for primary ovarian cancer management. A deeper …

Background Paclitaxel and carboplatin given every 3 weeks is standard treatment for
advanced ovarian carcinoma. Attempts to improve patient survival by including other drugs …

To reveal the antiangiogenic capability of cancer chemotherapy, we developed an
alternative antiangiogenic schedule for administration of cyclophosphamide. We show here …

Axelrod et al.(1958) first described the enzyme-catalyzed O-methylation of catecholamines
and other catechols in the late 1950s. The enzyme responsible for the O-methylation …

Background Carboplatin and paclitaxel administered every 3 weeks is standard-of-care first-
line chemotherapy for epithelial ovarian cancer. The Japanese JGOG3016 trial showed a …

Cytochrome P450 enzymes that metabolize estrogens are expressed in the mammary
gland, uterus, brain and other target tissues for estrogen action, and this results in the …

The impact of estrogen exposure in preventing or treating cardiovascular disease is
controversial. But it is clear that estrogen has important effects on vascular physiology and …