Quantitative unit operation models for the optimization and refinement of modern late-stage
biopharmaceutical drug manufacturing processes have recently attracted increasing …

In bioprocess engineering the Qualtiy by Design (QbD) initiative encourages the use of
models to define design spaces. However, clear guidelines on how models for QbD are …

The reverse osmosis (RO) process is widely utilized to reduce highly hazardous chemicals
in wastewater, resulting in decreased electrical conductivity and enhanced usability …

The calculation of temporally varying upstream process outcomes is a challenging task.
Over the last years, several parametric, semi-parametric as well as non-parametric …

Arsenic contamination in aqueous media is a serious environmental problem, especially in
developing countries. In this research, the Box-Behnken response surface methodology was …

Abstract Compliance with Quality by Design (QbD) constitutes a major challenge in
biopharmaceuticals. Monoclonal antibodies (mAbs) represent a significant …

The analysis of data collected using design of experiments (DoE) is the current gold
standard to determine the influence of input parameters and their interactions on process …

We present a new modeling approach for the study and prediction of important process
outcomes of biotechnological cultivation processes under the influence of process …

This thesis was developed during my time as research assistant at RWTH Aachen University
at the chair of Process Systems Engineering (AVT. SVT). To a great extent this thesis owes …