Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from …
W Zhang, Y Zhao, F Zhang, Q Wang, T Li, Z Liu… - Clinical …, 2020 - Elsevier
The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all
over the world. Reports from China showed that about 20% of patients developed severe …
over the world. Reports from China showed that about 20% of patients developed severe …
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against …
The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-
CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease …
CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease …
Potential role of flavivirus NS2B-NS3 proteases in viral pathogenesis and anti-flavivirus drug discovery employing animal cells and models: a review
Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …
world. There are very limited numbers of antivirals to combat flavivirus infection, and …
Viral proteases: Structure, mechanism and inhibition
J Zephyr, NK Yilmaz, CA Schiffer - The enzymes, 2021 - Elsevier
Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate
specificity. This chapter focuses on proteases from viruses that are relevant to human health …
specificity. This chapter focuses on proteases from viruses that are relevant to human health …
Inhibitors of the Zika virus protease NS2B-NS3
In recent years, the Zika virus has emerged from a neglected flavivirus to a health-
threatening pathogen that causes epidemic outbreaks associated with neurological …
threatening pathogen that causes epidemic outbreaks associated with neurological …
Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates
Repurposing of antirheumatic drugs has garnered global attention. The aim of this article is
to overview available evidence on the use of widely used antirheumatic drugs …
to overview available evidence on the use of widely used antirheumatic drugs …
[HTML][HTML] Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review
Background Repurposing hydroxychloroquine (HCQ) and chloroquine (CQ) as antiviral
agents is a re-emerging topic with the advent of new viral epidemics. Aims To summarize …
agents is a re-emerging topic with the advent of new viral epidemics. Aims To summarize …
Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia
A Vitiello, F Ferrara, C Pelliccia, G Granata… - Italian Journal of …, 2020 - italjmed.org
For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …
itself, but by an overactive inflammatory state. In fact, in some people the immune system …
Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy
JM Brimson, MI Prasanth, DS Malar… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Despite the availability of new vaccines for SARS-CoV-2, there has been slow
uptake and problems with supply in some parts of the world. Hence, there is still a necessity …
uptake and problems with supply in some parts of the world. Hence, there is still a necessity …