Developmental pathways in the pathogenesis of lung fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …
Wnt signaling in lung development, regeneration, and disease progression
CJ Aros, CJ Pantoja, BN Gomperts - Communications biology, 2021 - nature.com
The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells
AN Nabhan, DG Brownfield, PB Harbury, MA Krasnow… - Science, 2018 - science.org
Alveoli, the lung's respiratory units, are tiny sacs where oxygen enters the bloodstream. They
are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells …
are lined by flat alveolar type 1 (AT1) cells, which mediate gas exchange, and AT2 cells …
Emergence of a wave of Wnt signaling that regulates lung alveologenesis by controlling epithelial self-renewal and differentiation
Alveologenesis is the culmination of lung development and involves the correct temporal
and spatial signals to generate the delicate gas exchange interface required for respiration …
and spatial signals to generate the delicate gas exchange interface required for respiration …
[HTML][HTML] Preparing for the first breath: genetic and cellular mechanisms in lung development
EE Morrisey, BLM Hogan - Developmental cell, 2010 - cell.com
The mammalian respiratory system—the trachea and the lungs—arises from the anterior
foregut through a sequence of morphogenetic events involving reciprocal endodermal …
foregut through a sequence of morphogenetic events involving reciprocal endodermal …
Reck and Gpr124 are essential receptor cofactors for Wnt7a/Wnt7b-specific signaling in mammalian CNS angiogenesis and blood-brain barrier regulation
Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPCR, have been
implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular …
implicated in Wnt7a/Wnt7b signaling in the CNS vasculature. We show here that vascular …
[HTML][HTML] Targeted alveolar regeneration with Frizzled-specific agonists
Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …
specification and activity of stem cells in many species. How Wnt signaling is selectively …
Regulation of the pulmonary circulation in the fetus and newborn
Y Gao, JU Raj - Physiological reviews, 2010 - journals.physiology.org
During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …
functional changes occur to prepare the lung for the transition to air breathing. The …
Macrophage Wnt7b is critical for kidney repair and regeneration
Macrophages are required for tissue homeostasis through their role in regulation of the
immune response and the resolution of injury. Here we show, using the kidney as a model …
immune response and the resolution of injury. Here we show, using the kidney as a model …
Epithelial-mesenchymal interactions in pulmonary fibrosis
HA Chapman - Annual review of physiology, 2011 - annualreviews.org
Lung epithelial cells have emerged as a frequent target of injury, a driver of normal repair,
and a key element in the pathobiology of fibrotic lung diseases. An important aspect of …
and a key element in the pathobiology of fibrotic lung diseases. An important aspect of …