Review of 3D cell culture with analysis in microfluidic systems

AD Castiaux, DM Spence, RS Martin - Analytical Methods, 2019 - pubs.rsc.org
A review with 105 references that analyzes the emerging research area of 3D cell culture in
microfluidic platforms with integrated detection schemes. Over the last several decades a …

[HTML][HTML] based cell culture platform and its emerging biomedical applications

K Ng, B Gao, KW Yong, Y Li, M Shi, X Zhao, Z Li… - Materials Today, 2017 - Elsevier
Paper has recently attracted increasing attention as a substrate for various biomedical
applications. By modifying its physical and chemical properties, paper can be used as an …

The current landscape of 3D in vitro tumor models: what cancer hallmarks are accessible for drug discovery?

D Rodenhizer, T Dean, E D'Arcangelo… - Advanced …, 2018 - Wiley Online Library
Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …

Contributions of 3D cell cultures for cancer research

M Ravi, A Ramesh, A Pattabhi - Journal of cellular physiology, 2017 - Wiley Online Library
Cancer cell lines have contributed immensely in understanding the complex physiology of
cancers. They are excellent material for studies as they offer homogenous samples without …

Beyond wicking: expanding the role of patterned paper as the foundation for an analytical platform

SC Fernandes, JA Walz, DJ Wilson, JC Brooks… - 2017 - ACS Publications
While a number of assays for soluble analytes have been developed using paper-based
microfluidic devices, the detection and analysis of blood cells has remained an outstanding …

Exploring New Dimensions of Tumor Heterogeneity: The Application of Single Cell Analysis to Organoid‐Based 3D In Vitro Models

N Landon‐Brace, NT Li… - Advanced Healthcare …, 2023 - Wiley Online Library
Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to
investigating fundamental cancer biology and developing novel treatment strategies that …

A TRACER 3D Co-Culture tumour model for head and neck cancer

M Young, D Rodenhizer, T Dean, E D'Arcangelo, B Xu… - Biomaterials, 2018 - Elsevier
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
and have been shown to play an important role in the progression of cancer. To probe these …

Engineered paper‐based cell culture platforms

D Lantigua, YN Kelly, B Unal… - Advanced healthcare …, 2017 - Wiley Online Library
Paper is used in various applications in biomedical research including diagnostics,
separations, and cell cultures. Paper can be conveniently engineered due to its tunable and …

A pH-sensing optode for mapping spatiotemporal gradients in 3D paper-based cell cultures

RM Kenney, MW Boyce, NA Whitman… - Analytical …, 2018 - ACS Publications
Paper-based cultures are an emerging platform for preparing 3D tissue-like structures.
Chemical gradients can be imposed upon these cultures, generating microenvironments …

Evaluation of hybrid vesicles in an intestinal cell model based on structured paper chips

P De Dios Andres, IN Westensee, E Brodszkij… - …, 2021 - ACS Publications
Cell culture-based intestinal models are important to evaluate nanoformulations intended for
oral drug delivery. We report the use of a floating structured paper chip as a scaffold for …