Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …

Growing evidence has indicated that iron deposition is one of the key factors leading to
neuronal death in the neurodegenerative diseases. Ferritin is a hollow iron storage protein …

Background: Iron can catalyze damaging free radical reactions. With age, iron accumulates
in brain gray matter regions and may contribute to the risk of developing age-related …

Iron is an abundant transition metal that is essential for life, being associated with many
enzyme and oxygen carrier proteins involved in a variety of fundamental cellular processes …

Mitochondrial bioenergetic dysfunction is involved in neurodegeneration in Huntington's
disease (HD). Iron is critical for normal mitochondrial bioenergetics but can also contribute to …

The discovery of hepcidin clarified the basic mechanism of the control of systemic iron
homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by …

Alzheimer's disease (AD) is a degenerative disease of the nervous system. The typical
pathological changes of AD are Aβ deposition, neurofibrillary tangles, neuron loss, and …

Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …

Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. β-
amyloid plaque (Aβ) deposition and hyperphosphorylated tau, as well as dysregulated …