Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

P Kesika, N Suganthy, BS Sivamaruthi, C Chaiyasut - Life sciences, 2021 - Elsevier
Gut microbiota represents a diverse and dynamic population of microorganisms harboring
the gastrointestinal tract, which influences the host health and disease. Gut microbiota …

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Amyloid precursor protein processing and Alzheimer's disease

RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …

Alzheimer's disease and the amyloid-β peptide

MP Murphy, H LeVine III - Journal of Alzheimer's disease, 2010 - content.iospress.com
Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

PL McGeer, EG McGeer - Acta neuropathologica, 2013 - Springer
The amyloid cascade hypothesis is widely accepted as the centerpiece of Alzheimer
disease (AD) pathogenesis. It proposes that abnormal production of beta amyloid protein …

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

I Benilova, E Karran, B De Strooper - Nature neuroscience, 2012 - nature.com
The'toxic Aβ oligomer'hypothesis has attracted considerable attention among Alzheimer's
disease researchers as a way of resolving the lack of correlation between deposited amyloid …

Cholinergic differentiation of human neuroblastoma SH-SY5Y cell line and its potential use as an in vitro model for Alzheimer's disease studies

LM de Medeiros, MA De Bastiani, EP Rico… - Molecular …, 2019 - Springer
Cholinergic transmission is critical to high-order brain functions such as memory, learning,
and attention. Alzheimer's disease (AD) is characterized by cognitive decline associated …

Molecular mechanisms of amyloid oligomers toxicity

R Kayed, CA Lasagna-Reeves - Journal of Alzheimer's …, 2013 - content.iospress.com
Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This
hypothesis might explain the lack of correlation between amyloid plaques and memory …

Aβ oligomers–a decade of discovery

DM Walsh, DJ Selkoe - Journal of neurochemistry, 2007 - Wiley Online Library
Converging lines of evidence suggest that progressive accumulation of the amyloid β‐
protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …