Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as …

Cancer cells constantly face a fluctuating nutrient supply and interference with adaptive
responses might be an effective therapeutic approach. It has been discovered that in the …

There has been a striking generational increase in life-threatening food allergies in
Westernized societies,. One hypothesis to explain this rising prevalence is that twenty-first …

Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis.
Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed …

Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass surgery
(RYGBP) in humans has an intriguing effect: a rapid and substantial control of type 2 …

Stem cells are a unique source of self-renewing cells within the human body. Before the end
of the last millennium, adult stem cells, in contrast to their embryonic counterparts, were …

The kidneys are developed from the intermediate mesoderm of the embryo. They are
important for osmoregulation, regulation of acid-base balance, reabsorption of nutrients, and …

Metabolic reprogramming is fundamental to biological homeostasis, enabling cells to adjust
metabolic routes after sensing altered availability of fuels and growth factors. ULK1 and …

Background & Aims Intestinal microbiota modulate metabolism and associate closely with
epithelial cells in the intestine. In intestinal epithelial cells (IECs), histone deacetylase 3 …

The gluconeogenesis pathway, which has been known to normally present in the liver,
kidney, intestine, or muscle, has four irreversible steps catalyzed by the enzymes: pyruvate …