Carnosine is a naturally occurring dipeptide found in meat. Alternatively it can be formed
through synthesis from the amino acids, β-alanine and L-histidine. Carnosine has long been …

The growing global prevalence of diabetes mellitus (DM), along with its associated
complications, continues to rise. When clinically detected most DM complications are …

Background It has been reported that diabetes mellitus affects 435 million people globally as
a primary health care problem. Despite many therapies available, many diabetes remains …

Placental dysfunction can lead to fetal growth restriction which is associated with perinatal
morbidity and mortality. Fetal growth restriction increases the risk of obesity and diabetes …

Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation
pathways, which affect the translation of only a subset of messenger ribonucleic acid …

O-GlcNAc transferase (OGT), a nutrient sensor sensitive to glucose flux, is highly expressed
in the pancreas. However, the role of OGT in the mitochondria of β-cells is unexplored. In …

Background: Breast cancer (BRCA) is one of the most common cancers in women
worldwide and a leading cause of death from malignancy. This study was designed to …

The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-
fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since …

Protein O-GlcNAcylation is a nutrient and stress-sensitive protein post-translational
modification (PTM). The addition of an O-GlcNAc molecule to proteins is catalyzed by O …

Fetal growth restriction, or low birth weight, is a strong determinant for eventual obesity and
type 2 diabetes. Clinical studies suggest placental mechanistic target of rapamycin (mTOR) …