Key Clinical Points Osteoarthritis of the Knee Potential long-term consequences of knee
osteoarthritis include reduced physical activity, deconditioning, impaired sleep, fatigue …

The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

Objective To update and expand upon prior Osteoarthritis Research Society International
(OARSI) guidelines by developing patient-focused treatment recommendations for …

In recent years, the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for
Adult Cancer Pain have undergone substantial revisions focusing on the appropriate and …

Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

New treatment strategies have substantially changed the course of rheumatoid arthritis.
Many patients can achieve remission if the disease is recognised early and is treated …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective, widely used analgesics. For
the past 2 decades, considerable attention has been focused on their cardiovascular safety …

The increased risk of cardiovascular morbidity and mortality in rheumatoid arthritis and gout
has been increasingly acknowledged in past decades, with accumulating evidence that …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely recommended and prescribed to
treat pain in osteoarthritis. While measured to have a moderate effect on pain in …