During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …

Considerable progress towards an understanding of complex diseases has been made in
recent years due to the development of high-throughput genotyping technologies. Using …

Localization of causal variants underlying known risk loci is one of the main research
challenges following genome-wide association studies. Risk loci are typically dissected …

Genome-wide association studies (GWAS) have detected many disease associations.
However, the reported variants tend to explain small fractions of risk, and there are doubts …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Genetic studies in immune-mediated diseases have yielded a large number of disease-
associated loci. Here we review the progress being made in 12 such diseases, for which …

Large meta-analyses of rheumatoid arthritis (RA) susceptibility in European (EUR) and East
Asian (EAS) populations have identified> 100 RA risk loci, but genome-wide studies of RA in …

Genome-wide association studies (GWAS) in samples of European ancestry have identified
thousands of genetic variants associated with complex traits in humans. However, it remains …

Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating
quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early …

DNA methylation is an ideal trait to study the extent of the shared genetic control across
ancestries, effectively providing hundreds of thousands of model molecular traits with large …