An update on the progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem/stromal cells

DT Chu, TNT Phuong, NLB Tien, DK Tran… - International journal of …, 2020 - mdpi.com
Bone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent
cells, are widely used in the treatment of various diseases via their self-renewable …

Mesenchymal stromal cells and their secretome: new therapeutic perspectives for skeletal muscle regeneration

M Sandonà, L Di Pietro, F Esposito… - … in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are multipotent cells found in different tissues: bone
marrow, peripheral blood, adipose tissues, skeletal muscle, perinatal tissues, and dental …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

Pathogenic role of adipose tissue-derived mesenchymal stem cells in obesity and obesity-related inflammatory diseases

J Pestel, F Blangero, A Eljaafari - Cells, 2023 - mdpi.com
Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

Allogeneic bone marrow–derived mesenchymal stem cell safety in idiopathic Parkinson's disease

M Schiess, J Suescun, MF Doursout… - Movement …, 2021 - Wiley Online Library
Background Neuroinflammation plays a key role in PD pathogenesis, and allogeneic bone
marrow–derived mesenchymal stem cells can be used as an immunomodulatory therapy …

[HTML][HTML] A phase II clinical trial with repeated intrathecal injections of autologous mesenchymal stem cells in patients with amyotrophic lateral sclerosis

P Petrou, I Kassis, NE Yaghmour… - Frontiers in Bioscience …, 2021 - imrpress.com
Background: Mesenchymal stem cells (MSC) were shown to induce beneficial effects in
animal models of neurodegeneration and in pilot human trials in multiple sclerosis and …

Mesenchymal stem cells: a potential therapeutic approach for amyotrophic lateral sclerosis?

A Gugliandolo, P Bramanti… - Stem Cells International, 2019 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
degeneration of both upper and lower motor neurons. Patients show both motor and extra …

Status of ALS treatment, insights into therapeutic challenges and dilemmas

M Khamaysa, PF Pradat - Journal of Personalized Medicine, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is an extremely heterogeneous disease of motor
neurons that eventually leads to death. Despite impressive advances in understanding the …

Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials

SA Goutman, MG Savelieff, SA Sakowski… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of cortical,
brainstem, and spinal motor neurons; it causes progressive muscle weakness and atrophy …

Past and future of neurotrophic growth factors therapies in ALS: from single neurotrophic growth factor to stem cells and human platelet lysates

F Gouel, AS Rolland, JC Devedjian, T Burnouf… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that typically results
in death within 3–5 years after diagnosis. To date, there is no curative treatment and …