Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA footprint
ABSTRACT CRISPR technologies comprising a Cas nuclease and a guide RNA (gRNA)
can utilize multiple gRNAs to enact multi-site editing or regulation in the same cell. Nature …
can utilize multiple gRNAs to enact multi-site editing or regulation in the same cell. Nature …
HyperCas12a enables highly-multiplexed epigenome editing screens
SM Melore, MC Hamilton, TE Reddy - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Interactions between multiple genes or cis-regulatory elements (CREs) underlie a wide
range of biological processes in both health and disease. High-throughput screens using …
range of biological processes in both health and disease. High-throughput screens using …
Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR‐Cas3
CRISPR‐Cas systems provide researchers with eukaryotic genome editing tools and
therapeutic platforms that make it possible to target disease mutations in somatic organs …
therapeutic platforms that make it possible to target disease mutations in somatic organs …
Applied machine learning for the analysis of CRISPR-Cas systems
Y Yu - 2023 - search.proquest.com
Among the defense strategies developed in microbes over millions of years, the innate
adaptive CRISPR-Cas immune systems have spread across most of bacteria and archaea …
adaptive CRISPR-Cas immune systems have spread across most of bacteria and archaea …