PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

The size and extent of folding of the mammalian cerebral cortex are important factors that
influence a species' cognitive abilities and sensorimotor skills. Studies in various animal …

The majority of research on reactive oxygen species (ROS) has focused on their cellular
toxicities. Stem cells generally have been thought to maintain low levels of ROS as a …

PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

The mechanism by which adult neural stem cells (NSCs) are established during
development is unclear. In this study, analysis of cell cycle progression by examining …

MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the
regulation of gene expression. Evidence accumulating in the past decades indicate that they …

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …