Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond

M Sharma, N Suratannon, D Leung, S Baris… - Trends in …, 2024 - cell.com
Signal transducer and activator of transcription (STAT)-6 is a transcription factor central to
pro-allergic immune responses, although the function of human STAT6 at the whole …

Immunometabolism in the pathogenesis of asthma

Z Qin, Y Chen, Y Wang, Y Xu, T Liu, Q Mu… - …, 2024 - Wiley Online Library
Bronchial asthma is a heterogeneous disease characterised by chronic airway inflammation.
A variety of immune cells such as eosinophils, mast cells, T lymphocytes, neutrophils and …

Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis

K Petalas, J Goudakos, GN Konstantinou - International Journal of …, 2023 - mdpi.com
Chronic rhinosinusitis (CRS) with (CRSwNP) or without (CRSsNP) nasal polyps is a
prevalent and heterogeneous disorder existing as a spectrum of clinical conditions with …

Update on allergic fungal rhinosinusitis

AJ Chua, A Jafar, AU Luong - Annals of Allergy, Asthma & Immunology, 2023 - Elsevier
Allergic fungal rhinosinusitis (AFRS) is a unique clinical entity that falls under the broader
umbrella of chronic rhinosinusitis with nasal polyps with type 2 inflammation. It is …

[HTML][HTML] Daphnetin alleviates allergic airway inflammation by inhibiting T-cell activation and subsequent JAK/STAT6 signaling

JY Park, JW Lee, ES Oh, YN Song, MJ Kang… - European Journal of …, 2024 - Elsevier
Allergic asthma is a major health burden on society as a chronic respiratory disease
characterized by inflammation and muscle tightening around the airways in response to …

Unified airway disease: future directions

JG Ahmad, MJ Marino, AU Luong - Otolaryngologic Clinics of …, 2023 - oto.theclinics.com
Unified airway disease (UAD) describes the shared epidemiologic and pathophysiologic
relationship among the chronic inflammatory diseases of the upper and lower airways …

Lung proteomic and metabolomic changes induced by carbon black nanoparticles and high humidity in a mouse asthma model

R Deng, M Wang, KF Chung, Y Zhu - Environmental Pollution, 2025 - Elsevier
Allergic asthma is a significant international concern in respiratory health, which can be
exacerbated by the increasing levels of non-allergenic pollutants. This rise in airborne …

Scorpion venom polypeptide governs alveolar macrophage M1/M2 polarization to alleviate pulmonary fibrosis

L Xu, Y Zhang, Q Dai, N Lin, T Guan, X Song, S Hong - Tissue and Cell, 2022 - Elsevier
The onset of connective tissue disease-related interstitial lung disease (CTD-ILD) is
generally insidious and progressive, with pulmonary fibrosis in the middle stage, and …

Resveratrol Aerosol Inhalation Attenuates Ovalbumin (OVA)‐Induced Asthma in BALB/c Mouse Model

C Shan, Y Wu, L Tang, Y Lin, Z Ni… - Journal of Food …, 2024 - Wiley Online Library
Asthma is a common disease that affects millions of people but has no cure. Resveratrol
(Res) has been confirmed to be effective against asthma; however, in vivo experiments had …

Unified airway disease: genetics and epigenetics

T Brar, MJ Marino, D Lal - Otolaryngologic Clinics of North …, 2023 - oto.theclinics.com
The coexistence of upper and lower airway diseases (allergic rhinitis [AR]-asthma, AR-
chronic rhinosinusitis [CRS]-asthma; CRS-bronchitis/bronchiectasis) is now well recognized …