The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL
(a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess …

BAFF, APRIL and their receptors play important immunological roles, especially in the B cell
arm of the immune system. A number of splice isoforms have been described for both …

Ligands of the tumor necrosis factor superfamily (TNFSF)(4–1BBL, APRIL, BAFF, CD27L,
CD30L, CD40L, EDA1, EDA2, FasL, GITRL, LIGHT, lymphotoxin α, lymphotoxin αβ, OX40L …

The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas
APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF …

Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the
treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple …

BAFF plays a central role in B-lineage cell biology; however, the regulation of BAFF-binding
receptor (BBR) expression during B cell activation and differentiation is not completely …

BAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital
homeostatic cytokine for B cells that helps regulate both innate and adaptive immune …

Two major types of glycosaminoglycan (GAG) polysaccharides, heparan sulfate and
chondroitin sulfate, are polymerized and modified by enzymes that are encoded by more …

BAFF is a B cell survival factor that binds to three receptors BAFF-R, TACI and BCMA. BAFF-
R is the receptor triggering naïve B cell survival and maturation while BCMA supports the …

BACKGROUND: Mutations in the gene coding for transmembrane activator and calcium-
modulating cyclophilin ligand interactor (TACI) have been identified in common variable …