Osteoarthritis is a debilitating disease that has increased in prevalence across the world due
to the aging population. Currently, physicians use a plethora of treatment strategies to try …

Background: Viscosupplementation, the intra-articular injection of hyaluronic acid, is widely
used for symptomatic knee osteoarthritis. Purpose: To assess the benefits and risks of …

Objective To evaluate the therapeutic trajectory of intra-articular hyaluronic acid (IAHA) vs
placebo for knee osteoarthritis (OA). Design Our data sources include Medline, EMBASE …

Background Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is
associated with significant pain and disability. Objectives To assess the effects of …

Background: Knee osteoarthritis (OA) is a common and often disabling joint disorder among
adults that may result in impaired activity and daily function. A variety of treatment options …

Background: Placebo controls are essential in evaluating the effectiveness of medical
treatments. Although it is unclear whether different placebo interventions for osteoarthritis …

We conducted a systematic review and meta-analysis of randomized saline-controlled trials
to determine the safety and efficacy of US-approved intra-articular hyaluronic acid (IAHA) …

OBJECTIVE: To summarize literature on the concurrent and predictive validity of MRI-based
measures of osteoarthritis (OA) structural change. METHODS: An online literature search …

Osteoarthritis (OA) is a degenerative joint disease that causes persistent joint pain and
stiffness of mainly the large peripheral weight-bearing joints. It is a leading cause of …

Objectives Hyaluronic acid and corticosteroids are common intra-articular (IA) therapies
widely used for the management of mild to moderate knee osteoarthritis (OA). Many trials …