The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

Resistance to rifampin (RIF) and rifabutin (RFB) in Mycobacterium tuberculosis is associated
with mutations within an 81-bp region of the rpoB gene (RIF resistance-determining region …

Summary Since 1967, Rifampin (RMP, a Rifamycin) has been used as a first line antibiotic
treatment for tuberculosis (TB), and it remains the cornerstone of current short‐term TB …

Covering: 2011 to 2021 The structural division of ansamycins, including those of atypical
cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid …

NusG is a transcription elongation factor that stimulates transcription pausing in Gram+
bacteria including B. subtilis by sequence-specific interaction with a conserved pause …

Conspectus Rifamycin antibiotics include the WHO essential medicines rifampin, rifabutin,
and rifapentine. These are semisynthetic derivatives of the natural product rifamycins …

Background Improving our understanding of the relationship between the genotype and the
drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more …

Rifabutin is a spiro-piperidyl-rifamycin structurally closely related to rifampicin that shares
many of its properties. We attempted to address the reasons why this drug, which was …

Antibiotic-resistant bacterial pathogens pose an urgent healthcare threat, prompting a
demand for new medicines. We report the mode of action of the natural ansamycin antibiotic …