Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Apolipoprotein (apo) E has a storied history as a lipid transport protein. The integral
association between cholesterol homeostasis and lipoprotein clearance from circulation are …

Negative stain electron microscopy (EM) allows relatively simple and quick observation of
macromolecules and macromolecular complexes through the use of contrast enhancing …

Commonly used methods for determining protein structure, including X-ray crystallography
and single-particle reconstruction, often provide a single and unique three-dimensional (3D) …

Large-scale and continuous conformational changes in the RNA self-folding process
present significant challenges for structural studies, often requiring trade-offs between …

Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl
ester mass from atheroprotective high-density lipoproteins to atherogenic low-density …

Plasma lipoprotein levels are predictors of risk for coronary artery disease. Lipoprotein
structure-function relationships provide important clues that help identify the role of …

In this personal, historic account of macromolecular transmission electron microscopy
(TEM), published data from the 1940s through to recent times is surveyed, within the context …

Structural determination of proteins is rather challenging for proteins with molecular masses
between 40-200 kDa. Considering that more than half of natural proteins have a molecular …

The cation-independent mannose 6-phosphate receptor (CI-MPR) is clinically significant in
the treatment of patients with lysosomal storage diseases because it functions in the …