Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

DY Shu, FJ Lovicu - Progress in retinal and eye research, 2017 - Elsevier
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …

[PDF][PDF] Citicoline: pharmacological and clinical review, 2010 update

JJ Secades - Rev Neurol, 2011 - researchgate.net
This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …

Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension

H Tanihara, T Inoue, T Yamamoto, Y Kuwayama… - American journal of …, 2013 - Elsevier
Purpose To identify the optimal dose of a novel Rho kinase inhibitor, K-115, by assessing
dose dependency of the intraocular pressure (IOP)-lowering effects and the safety in …

Posterior segment ophthalmic drug delivery: Role of muco-adhesion with a special focus on chitosan

AM Burhan, B Klahan, W Cummins, V Andrés-Guerrero… - Pharmaceutics, 2021 - mdpi.com
Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and
diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide …

[PDF][PDF] Citicoline: pharmacological and clinical review, 2016 update

JJ Secades - Rev Neurol, 2016 - article.imrpress.com
This review is based on the previous one published in 2010–Secades JJ. Citicoline:
pharmacological and clinical review, 2010 update. Rev Neurol 2011; 52 (Suppl 2): S1-62 …

Current perspective of neuroprotection and glaucoma

K Tian, S Shibata-Germanos, M Pahlitzsch… - Clinical …, 2015 - Taylor & Francis
Glaucoma is the second leading cause of blindness worldwide and is most notably
characterized by progressive optic nerve atrophy and advancing loss of retinal ganglion …

Benefits of switching from latanoprost to preservative-free tafluprost eye drops: a meta-analysis of two Phase IIIb clinical trials

H Uusitalo, E Egorov, K Kaarniranta… - Clinical …, 2016 - Taylor & Francis
Introduction Glaucoma patients frequently exhibit ocular surface side effects during
treatment with prostaglandin eye drops. The present work investigated whether glaucoma …

Long term glaucoma drug delivery using a topically retained gel/microsphere eye drop

MV Fedorchak, IP Conner, JS Schuman, A Cugini… - Scientific reports, 2017 - nature.com
The purpose of this study was to characterize and determine the efficacy of a long-term, non-
invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is …

[HTML][HTML] Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma

RK Somvanshi, S Zou, S Kadhim, S Padania… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Objectives Glaucoma is characterized by progressive damage of the retinal ganglion cells
(RGCs), resulting in irreversible vision loss. Cannabinoids (CBs) ameliorate several factors …

Discovery of molecular therapeutics for glaucoma: challenges, successes, and promising directions: miniperspective

RK Donegan, RL Lieberman - Journal of medicinal chemistry, 2016 - ACS Publications
Glaucoma, a heterogeneous ocular disorder affecting∼ 60 million people worldwide, is
characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in …