Mast cells are evolutionarily old cells and the principal effectors in allergic responses and
inflammation. They are seeded from the yolk sac during embryogenesis or are derived from …

Collapse of endocannabinoid (eCB) signaling in the amygdala contributes to stress-induced
anxiety, but the mechanisms of this effect remain unclear. eCB production is tied to the …

Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling, interfering with its
control of glucose homeostasis and metabolism. PTP1B activity is elevated in obesity and …

To understand the contribution of intrinsic membrane properties to the different in vivo firing
patterns of oxytocin (OT) and vasopressin (VP) neurones, in vitro studies are needed, where …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in the
progressive decline of cognitive function in patients. Familial forms of AD are tied to …

Schizophrenia, a complex neuropsychiatric disorder, frequently experiences a high rate of
misdiagnosis due to subjective symptom assessment. Consequently, there is an urgent …

Cytotoxic effects of cisplatin occur primarily through apoptosis. Though several pro-and anti-
apoptotic signaling molecules have been identified to play an important role in mediating the …

Mutations in the beta-amyloid protein (APP) cause familial Alzheimer's disease. In hAPP-J20
mice expressing mutant APP, pharmacological inhibition or genetic ablation of the tyrosine …

Subanesthetic doses of ketamine induce schizophrenia-like behaviors in mice including
hyperlocomotion and deficits in working memory and sensorimotor gating. Here, we …

Insulin action at the hypothalamus controls glucose homeostasis by suppressing hepatic
glucose production and promoting glucose uptake by muscle. However, the mechanisms …