In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

In-cell NMR spectroscopy provides precious structural and functional information on
biological macromolecules in their native cellular environment at atomic resolution …

In‐cell NMR spectroscopy is a powerful tool to investigate protein behavior in physiologically
relevant environments. Although proven valuable for disordered proteins, we show that in …

Degraders have illustrated that compound‐induced proximity to E3 ubiquitin ligases can
prompt the ubiquitination and degradation of disease‐relevant proteins. Hence, this …

In-cell NMR can investigate protein conformational changes at atomic resolution, such as
those changes induced by drug binding or chemical modifications, directly in living human …

In-cell NMR spectroscopy is a powerful approach to study protein structure and function in
the native cellular environment. It provides precious insights into the folding, maturation …

Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically
disrupt bacterial membranes. Despite extensive research, the precise mode of action of …