Aligning timing of nutritional intake, physical activity, and/or medication with circadian
rhythms are potential strategies to reset peripheral circadian rhythms and may enhance ICU …

The Earth's 24-h planetary rotation, with predictable light and heat cycles, has driven
profound evolutionary adaptation, with prominent impacts on physiological mechanisms …

Background & Aims Chronic circadian dysfunction increases the risk of non-alcoholic fatty
liver disease (NAFLD)-related hepatocellular carcinoma (HCC), but the underlying …

Circadian dysrhythmias occur commonly in critically ill patients reflecting variable effects of
underlying illness, ICU environment, and treatments. We retrospectively analyzed the …

Improved understanding of the etiologies of delirium, a common and severe
neuropsychiatric syndrome, would facilitate the disease prevention and treatment. Here, the …

The circadian clock network is an evolutionarily conserved system that regulates systemic
metabolism, such as glucose homeostasis. Intestinal tissue is a pivotal organ for the …

Background Despite the intensive efforts to improve the diagnosis and therapy of sepsis
over the last decade, the mortality of septic shock remains high and causes substantial …

Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of
mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of …

OBJECTIVES: Nonpharmacologic delirium management is recommended by current
guidelines, but studies on the impact of ICU design are still limited. The study's primary …

Further investigation is needed to establish the clinical relevance of sleep and circadian
disruption in the ICU. For interventions, standardized protocols of sleep promotion bundles …