Genetic dissection of mammalian fertility pathways

MM Matzuk, DJ Lamb - Nature Medicine, 2002 - nature.com
The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

The dsRNA binding protein family: critical roles, diverse cellular functions

LR Saunders, GN Barber - The FASEB Journal, 2003 - Wiley Online Library
The dsRNA binding proteins (DRBPs) comprise a growing family of eukaryotic, prokaryotic,
and viral‐encoded products that share a common evolutionarily conserved motif specifically …

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of …

L Hermo, RM Pelletier, DG Cyr… - … research and technique, 2010 - Wiley Online Library
Spermiogenesis is a long process whereby haploid spermatids derived from the meiotic
divisions of spermatocytes undergo metamorphosis into spermatozoa. It is subdivided into …

Oviductal secretion and gamete interaction

S Ghersevich, E Massa, C Zumoffen - Reproduction, 2015 - rep.bioscientifica.com
A reliable, easy to assess marker for fertility in agricultural species would be highly desirable
and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes …

m6A mRNA modification regulates mammalian spermatogenesis

Z Lin, MH Tong - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2019 - Elsevier
Mammalian spermatogenesis is a highly specialized differentiation process involving
precise regulatory mechanisms at the transcriptional, posttranscriptional, and translational …

Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs

YH Sun, RH Wang, K Du, J Zhu, J Zheng… - Nature …, 2021 - nature.com
PIWI-interacting small RNAs (piRNAs) protect the germline genome and are essential for
fertility. piRNAs originate from transposable element (TE) RNAs, long non-coding RNAs, or …

Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule

D Yamada, M Yoshida, YN Williams… - … and Cellular Biology, 2006 - Taylor & Francis
TSLC1/IGSF4, an immunoglobulin superfamily molecule, is predominantly expressed in the
brain, lungs, and testes and plays important roles in epithelial cell adhesion, cancer …

Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

A Harashima, T Guettouche… - Genes & …, 2010 - genesdev.cshlp.org
Here, we describe a new mechanism of host defense that involves the nuclear factors
associated with dsRNA (NFAR1 [90 kDa] and NFAR2 [110 kDa]), which constitute part of the …

Analysis of microRNA expression in the prepubertal testis

GM Buchold, C Coarfa, J Kim, A Milosavljevic… - PloS one, 2010 - journals.plos.org
Only thirteen microRNAs are conserved between D. melanogaster and the mouse; however,
conditional loss of miRNA function through mutation of Dicer causes defects in proliferation …

NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3′-untranslated region of MyoD and p21WAF1/CIP1 mRNAs

L Shi, G Zhao, D Qiu, WR Godfrey, H Vogel… - Journal of Biological …, 2005 - ASBMB
NF90 and splice variant NF110/ILF3/NFAR are double-stranded RNA-binding proteins that
regulate gene expression. Mice with targeted disruption of NF90 were engineered. NF90 …