Transdermal drug delivery: 30+ years of war and still fighting!

S Wiedersberg, RH Guy - Journal of controlled Release, 2014 - Elsevier
By any measure, transdermal drug delivery (TDD) is a successful controlled release
technology. Over the last 30+ years, a steady flux of transdermal products have received …

Iontophoretic skin delivery systems: Success and failures

P Bakshi, D Vora, K Hemmady, AK Banga - International Journal of …, 2020 - Elsevier
Iontophoretic transdermal delivery uses a small electric current to push charged molecules
into the skin under an electrode of same polarity and offers an attractive option to facilitate …

Microneedles for drug delivery: trends and progress

K Cheung, DB Das - Drug delivery, 2016 - Taylor & Francis
In recent years, there has been a surge in the research and development of microneedles
(MNs), a transdermal delivery system that combines the technology of transdermal patches …

Microneedles for gene and drug delivery in skin cancer therapy

D Zhi, T Yang, T Zhang, M Yang, S Zhang… - Journal of Controlled …, 2021 - Elsevier
The success of skin cancer treatment is severely limited in the route of administration
because most genes and drugs cannot break through the excellent stratum corneum (SC) …

Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules

A Fortuna, G Alves, A Serralheiro, J Sousa… - European Journal of …, 2014 - Elsevier
As a non-invasive route, intranasal administration offers patient comfort and compliance
which are hurdled in parenteral drug therapy. In addition, the current recognition that the …

Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes

JO Morales, KR Fathe, A Brunaugh, S Ferrati, S Li… - The AAPS journal, 2017 - Springer
Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which
have already produced many new drugs for clinical use in the last decades. Due to the …

Physicochemical and formulation developability assessment for therapeutic peptide delivery—a primer

A Bak, D Leung, SE Barrett, S Forster, EC Minnihan… - The AAPS journal, 2015 - Springer
Peptides are an important class of endogenous ligands that regulate key biological
cascades. As such, peptides represent a promising therapeutic class with the potential to …

Effective transcutaneous immunization using a combination of iontophoresis and nanoparticles

DS Bernardi, C Bitencourt, DSC da Silveira… - … , Biology and Medicine, 2016 - Elsevier
Needle-free immunization strategies have been sought for years. Transcutaneous
immunization using electroporation has been studied, but the high electrical voltage that …

Research progress of physical transdermal enhancement techniques in tumor therapy

W Han, F Liu, G Liu, H Li, Y Xu, S Sun - Chemical Communications, 2023 - pubs.rsc.org
The advancement and popularity of transdermal drug delivery (TDD) based on the physical
transdermal enhancement technique (PTET) has opened a new paradigm for local tumor …

Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention

S Xiao, Y Yan, J Zhao, Y Zhang, N Feng - International Journal of …, 2020 - Elsevier
The aim of this research was to improve transdermal delivery and distribution of
tetramethylpyrazine (TMP) in the brain, by adding borneol (BN) and iontophoresis (ITP), and …