Background Bipolar disorder affects up to one in 25 individuals and identification of early
risk indicators of negative outcomes could facilitate early detection of patients with greatest …

Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

There is a substantial body of research reporting evidence of associations between various
forms of childhood adversity and psychosis, across the spectrum from experiences to …

There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …

Evidence for the association between childhood trauma and psychosis is well supported
and continues to grow. In a recent sample of more than 4000 children, Croft and colleagues …

Objective: To carry out a systematic review of the literature addressing cognitive functions in
first-episode psychosis (FEP), divided into domains. Although this is not a full “cognitive …

Altered hippocampal morphology and reduced volumes have been found in children born
preterm compared to full-term. Stress inhibits neurogenesis in the hippocampus, and …

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes
neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the …

Objective: To present a systematic review of the literature on the associations between early
social environment, early life adversity, and social cognition in major psychiatric disorders …