Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action

MJ Millan - Therapeutic Advances in Psychopharmacology, 2022 - journals.sagepub.com
Generalized anxiety disorder (GAD), the most frequently diagnosed form of anxiety, is
usually treated by cognitive-behavioural approaches or medication; in particular …

Transcriptomic mapping of the 5-HT receptor landscape

R De Filippo, D Schmitz - Patterns, 2024 - cell.com
Summary Serotonin (5-HT) is crucial for regulating brain functions such as mood, sleep, and
cognition. This study presents a comprehensive transcriptomic analysis of 5-HT receptors …

Therapeutic strategies against metabolic imbalance in a male mouse model with 5-HT2CR loss-of-function

H Liu, Z Liu, HXK Wong, N Xu, Q Liu, Y Li, Y Liu… - …, 2024 - academic.oup.com
Abstract The serotonin 2C receptor (5-HT 2C R)-melanocortin pathway plays well-
established roles in the regulation of feeding behavior and body weight homeostasis …

Unraveling the periprandial changes in brain serotonergic activity and its correlation with food intake-related neuropeptides in rainbow trout Oncorhynchus mykiss

M Chivite, RM Ceinos, JM Cerdá-Reverter… - Frontiers in …, 2023 - frontiersin.org
This study explored changes in brain serotonin content and activity together with
hypothalamic neuropeptide mRNA abundance around feeding time in rainbow trout, as well …

NU-1223, a simplified analog of alstonine, with 5-HT2cR agonist-like activity, rescues memory deficit and positive and negative symptoms in subchronic phencyclidine …

L Rajagopal, S Mahjour, M Huang, CA Ryan… - Behavioural Brain …, 2023 - Elsevier
Abstract The serotonin (5-HT) 2 C receptor (R) is a widely distributed G-protein-coupled
receptor, expressed abundantly in the central nervous system. Alstonine is a natural product …

The polymorphisms of candidate pharmacokinetic and pharmacodynamic genes and their pharmacogenetic impacts on the effectiveness of risperidone maintenance …

SAR Shilbayeh, IS Adeen, AS Alhazmi… - European Journal of …, 2024 - Springer
Background Antipsychotics, including risperidone (RIS), are frequently indicated for various
autism spectrum disorder (ASD) manifestations; however,“actionable” PGx testing in …

Lorcaserin inhibit glucose-stimulated insulin secretion and calcium influx in murine pancreatic islets

M Jing, S Wang, D Li, Z Wang, Z Li, Y Lu… - Frontiers in …, 2021 - frontiersin.org
Lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-
HT2CR) that is FDA approved for the long-term management of obesity with or without at …

Antibiotic treatment inhibits paclitaxel chemotherapy-induced activity deficits in female mice

CV Grant, K Jordan, MM Seng, LM Pyter - Plos one, 2023 - journals.plos.org
Chemotherapy, a mainstay in the treatment of cancer, is associated with severe and
debilitating side effects. Side effects can be physical (eg, gastrointestinal distress, anemia …

[HTML][HTML] Is Obesity Inherited?: Htr2c variants in human obesity

ES Yoo, JW Sohn - Molecules and cells, 2023 - ncbi.nlm.nih.gov
Is Obesity Inherited? - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI
Homepage MyNCBI Homepage Main Content Main Navigation Preview improvements coming …

Agomelatine: pharmacological profile, possible application, advantages

VE Medvedev, OV Kotova, AV Palin… - Neurology …, 2024 - nnp.ima-press.net
Аннотация Агомелатин–антидепрессант с уникальным фармакологическим действием,
одновременно являющийся агонистом мелатонина и селективным антагонистом …