The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry

K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Boron in drug design: Recent advances in the development of new therapeutic agents

GFS Fernandes, WA Denny, JL Dos Santos - European Journal of …, 2019 - Elsevier
Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …

Boron-Containing heterocycles as promising pharmacological agents

BC Das, MA Shareef, S Das, NK Nandwana… - Bioorganic & Medicinal …, 2022 - Elsevier
The incorporation of the “magic” boron atom has been established as an important new
strategy in the field of medicinal chemistry as boron compounds have been shown to form …

Organoboron compounds: Effective antibacterial and antiparasitic agents

PS Coghi, Y Zhu, H Xie, NS Hosmane, Y Zhang - Molecules, 2021 - mdpi.com
The unique electron deficiency and coordination property of boron led to a wide range of
applications in chemistry, energy research, materials science and the life sciences. The use …

Effects of boron-containing compounds on immune responses: review and patenting trends

KS Romero-Aguilar, IM Arciniega-Martínez… - Expert Opinion on …, 2019 - Taylor & Francis
Introduction: Boron-containing compounds induce effects on immune responses. Such
effects are interesting to the biomedical field for the development of therapeutic tools to …

Novel Treatment Approaches to Combat Trichomoniasis, a Neglected and Sexually Transmitted Infection Caused by Trichomonas vaginalis: Translational …

GV Rigo, LA Frank, GB Galego, ALS Santos, T Tasca - Venereology, 2022 - mdpi.com
The multistep translational science behind new drugs comprehends the entire process
through laboratory, clinical, and community observations turned into health interventions …

Antimalarial activity of novel class of 1, 3‐benzoxaborole derivatives containing 1, 3, 4‐oxadiazole moiety

V Adimule, AH Jagadeesha Gowda… - … for Malaria: Novel …, 2022 - Wiley Online Library
In the present research, series of 1, 3‐bezoxoborole containing 1, 3, 4‐oxadiazole
compounds was designed and synthesised by microwave cyclisation (MWC) using 1, 3 …

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives

AI Zulu, OO Oderinlo, C Kruger, M Isaacs, HC Hoppe… - Molecules, 2020 - mdpi.com
With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a
cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in …

Synthesis and in vitro antiprotozoal evaluation of novel metronidazole–Schiff base hybrids

RM Beteck, M Isaacs, LJ Legoabe… - Archiv der …, 2023 - Wiley Online Library
Herein we report the synthesis of 21 novel small molecules inspired by metronidazole and
Schiff base compounds. The compounds were evaluated against Trichomonas vaginalis …