Histones: at the crossroads of peptide and protein chemistry
MM Müller, TW Muir - Chemical reviews, 2015 - ACS Publications
1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …
Combinations of histone post-translational modifications
Histones are essential proteins that package the eukaryotic genome into its physiological
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) …
[HTML][HTML] Deciphering post-translational modification codes
Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair
KY Hsiao, CA Mizzen - Journal of molecular cell biology, 2013 - academic.oup.com
Abstract 53BP1 and other DNA damage response (DDR) proteins form foci at double-strand
breaks (DSBs) which promote their repair by nonhomologous end joining (NHEJ). Focal …
breaks (DSBs) which promote their repair by nonhomologous end joining (NHEJ). Focal …
Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9
RE Mansfield, CA Musselman, AH Kwan… - Journal of Biological …, 2011 - ASBMB
A major challenge in chromatin biology is to understand the mechanisms by which
chromatin is remodeled into active or inactive states as required during development and …
chromatin is remodeled into active or inactive states as required during development and …
Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain
Post-translational modifications (PTMs) of proteins are biochemical processes required for
cellular functions and signalling that occur in every sub-cellular compartment. Multiple …
cellular functions and signalling that occur in every sub-cellular compartment. Multiple …
Chromatin as an expansive canvas for chemical biology
Chromatin is extensively chemically modified and thereby acts as a dynamic signaling
platform controlling gene function. Chromatin regulation is integral to cell differentiation …
platform controlling gene function. Chromatin regulation is integral to cell differentiation …
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
CA Musselman, RE Mansfield, AL Garske… - Biochemical …, 2009 - portlandpress.com
CHD4 (chromodomain helicase DNA-binding protein 4) ATPase is a major subunit of the
repressive NuRD (nucleosome remodelling and deacetylase) complex, which is involved in …
repressive NuRD (nucleosome remodelling and deacetylase) complex, which is involved in …
The significance, development and progress of high-throughput combinatorial histone code analysis
The physiological state of eukaryotic DNA is chromatin. Nucleosomes, which consist of DNA
in complex with histones, are the fundamental unit of chromatin. The post-translational …
in complex with histones, are the fundamental unit of chromatin. The post-translational …
Combinatorial profiling of chromatin binding modules reveals multisite discrimination
AL Garske, SS Oliver, EK Wagner… - Nature chemical …, 2010 - nature.com
Specific interactions between post-translational modifications (PTMs) and chromatin-binding
proteins are central to the idea of a'histone code'. Here, we used a 5,000-member, PTM …
proteins are central to the idea of a'histone code'. Here, we used a 5,000-member, PTM …