Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods

BR Rushing, MI Selim - Food and chemical toxicology, 2019 - Elsevier
Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are
known to contaminate a large portion of the world's food supply. Aflatoxin B1 (AFB1) is the …

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

K Taguchi, H Motohashi, M Yamamoto - Genes to cells, 2011 - Wiley Online Library
The Keap1–Nrf2 regulatory pathway plays a central role in the protection of cells against
oxidative and xenobiotic damage. Under unstressed conditions, Nrf2 is constantly …

Mycotoxins in a changing global environment–a review

AG Marroquín-Cardona, NM Johnson… - Food and Chemical …, 2014 - Elsevier
Mycotoxins are toxic metabolites produced by fungal species that commonly contaminate
staple foods and feeds. They represent an unavoidable problem due to their presence in …

[HTML][HTML] Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions

JH Williams, TD Phillips, PE Jolly, JK Stiles… - The American journal of …, 2004 - Elsevier
Aflatoxins are well recognized as a cause of liver cancer, but they have additional important
toxic effects. In farm and laboratory animals, chronic exposure to aflatoxins compromises …

The emerging role of the Nrf2–Keap1 signaling pathway in cancer

MC Jaramillo, DD Zhang - Genes & development, 2013 - genesdev.cshlp.org
The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])–Keap1 (Kelch-like
erythroid cell-derived protein with CNC homology [ECH]-associated protein 1) signaling …

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology

TW Kensler, BD Roebuck, GN Wogan… - Toxicological …, 2011 - academic.oup.com
Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous
contaminants of the human food supply throughout the economically developing world. The …

Cancer burden in the year 2000. The global picture

DM Parkin, FI Bray, SS Devesa - European journal of cancer, 2001 - ejcancer.com
Although the general idea of 'burden'of a disease to a community seems fairly
straightforward, there are multiple dimensions in which it may be expressed, either in terms …

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism

Y Mitsuishi, H Motohashi, M Yamamoto - Frontiers in oncology, 2012 - frontiersin.org
The Keap1–Nrf2 [Kelch-like ECH-associated protein 1–nuclear factor (erythroid-derived 2)-
like 2] pathway plays a central role in the protection of cells against oxidative and xenobiotic …

Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid

EO Farombi, O Owoeye - … journal of environmental research and public …, 2011 - mdpi.com
Recently, considerable attention has been focused on dietary and medicinal phytochemicals
that inhibit, reverse or retard diseases caused by oxidative and inflammatory processes …

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease

KT Liby, MB Sporn, TA Esbenshade - Pharmacological reviews, 2012 - Elsevier
We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …