Application of atomic force microscopy in cancer research

X Deng, F Xiong, X Li, B Xiang, Z Li, X Wu… - Journal of …, 2018 - Springer
Atomic force microscopy (AFM) allows for nanometer-scale investigation of cells and
molecules. Recent advances have enabled its application in cancer research and diagnosis …

AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

A Stylianou, M Lekka, T Stylianopoulos - Nanoscale, 2018 - pubs.rsc.org
Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Mechanical properties of single cells: Measurement methods and applications

Y Hao, S Cheng, Y Tanaka, Y Hosokawa… - Biotechnology …, 2020 - Elsevier
Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

Atomic force microscopy on biological materials related to pathological conditions

A Stylianou, SV Kontomaris, C Grant… - Scanning, 2019 - Wiley Online Library
Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

Tissue rheology as a possible complementary procedure to advance histological diagnosis of colon cancer

P Deptuła, D Łysik, K Pogoda, M Ciesluk… - ACS Biomaterials …, 2020 - ACS Publications
In recent years, rheological measurements of cells and tissues at physiological and
pathological stages have become an essential method to determine how forces and …

A review of the biomechanical properties of single extracellular vesicles

M LeClaire, J Gimzewski, S Sharma - Nano Select, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are a unique, heterogeneous class of biological nanoparticles
secreted by most cells. As potential a class of novel diagnostics and therapeutics, the physio …

Enabling autonomous scanning probe microscopy imaging of single molecules with deep learning

J Sotres, H Boyd, JF Gonzalez-Martinez - Nanoscale, 2021 - pubs.rsc.org
Scanning probe microscopies allow investigating surfaces at the nanoscale, in real space
and with unparalleled signal-to-noise ratio. However, these microscopies are not used as …

The role of convolutional neural networks in scanning probe microscopy: a review

I Azuri, I Rosenhek-Goldian… - Beilstein journal of …, 2021 - beilstein-journals.org
Progress in computing capabilities has enhanced science in many ways. In recent years,
various branches of machine learning have been the key facilitators in forging new paths …

Recent advances in AFM-based biological characterization and applications at multiple levels

W Liang, H Shi, X Yang, J Wang, W Yang, H Zhang… - Soft Matter, 2020 - pubs.rsc.org
Atomic force microscopy (AFM) has found a wide range of bio-applications in the past few
decades due to its ability to measure biological samples in natural environments at a high …

Atomic Force Microscopy Methods to Measure Tumor Mechanical Properties

J Najera, MR Rosenberger, M Datta - Cancers, 2023 - mdpi.com
Simple Summary Atomic force microscopy (AFM) is a powerful technique that has been
pivotal to cancer research, but it has only recently been used to study tumor pathology at the …